Prozone Effect in RPR Testing: An ASCP Study Guide
Prozone Effect in RPR Testing: An ASCP Study Guide Can excess antibody make a test appear negative? Yes—the prozone effect is an important example. Why it happens Rapid plasma reagin (RPR) testing depends on visible flocculation. When antibodies are excessive, they can interfere with the cross-linking needed to produce a visible reaction. An undiluted specimen
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